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Related Experiment Video

Updated: Apr 22, 2026

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Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes.

Didac Vidal-Piñeiro1, Cinta Valls-Pedret2, Sara Fernández-Cabello1

  • 1Departament de Psiquiatria i Psicobiologica Clinica, Facultat de Medicina, Universitat de Barcelona Barcelona, Spain.

Frontiers in Aging Neuroscience
|October 14, 2014
PubMed
Summary

Brain aging involves declining connectivity, particularly in the Default Mode Network (DMN). This study links reduced DMN connectivity in elders to white and gray matter integrity, suggesting it

Keywords:
Default Mode Networkagingarterial spin labelingconnectivitygray mattermemoryresting-state fmriwhite matter

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Area of Science:

  • Neuroimaging
  • Gerontology
  • Cognitive Neuroscience

Background:

  • Aging is associated with cognitive and motor decline, alongside structural and functional brain changes.
  • Reduced Default Mode Network (DMN) connectivity is a proposed hallmark of brain aging, impacting cognitive function.
  • The relationship between age-related DMN connectivity changes and other neuroimaging markers is not fully understood.

Purpose of the Study:

  • To investigate the relationship between antero-posterior DMN connectivity and measures of white matter (WM) integrity, gray matter (GM) integrity, and cerebral blood flow (CBF) in healthy older adults.
  • To determine if DMN connectivity changes correlate with specific structural integrity markers and neurovascular measures in aging.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (fMRI) to assess DMN connectivity in 116 healthy elders.
  • Measured WM and GM integrity and CBF using arterial spin labeling (ASL) sequences.
  • Compared age-effect maps derived from a separate sample of young and old subjects to identify age-related vulnerability patterns.

Main Results:

  • Replicated findings of decreased DMN connectivity with aging and its association with memory performance.
  • Found that antero-posterior DMN functional connectivity correlated with WM and GM integrity, but not with CBF.
  • Identified DMN areas and the cingulum bundle as key correlates of antero-posterior DMN connectivity, mirroring age-related vulnerability patterns.

Conclusions:

  • Antero-posterior DMN connectivity is closely linked to the structural integrity of gray and white matter in aging brains.
  • This connectivity measure may serve as a sensitive indicator of brain aging processes.
  • The findings contribute to understanding DMN connectivity dysfunctions in aging through a comprehensive neuroimaging approach.