Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychological and socioeconomic impact of long-term home management on patients with left ventricular assist devices and their caregivers: a nationwide multicenter questionnaire survey.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same author

Pharmacologic Alteration of Meibum Lipid Composition Alleviates Dry Eye Phenotype in Awat2-/- Mice.

Investigative ophthalmology & visual science·2026
Same author

Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future.

Investigative ophthalmology & visual science·2026
Same author

One-year clinical outcomes of the EXCLUDER Conformable device in patients with an angulated proximal neck (Japanese Multicenter Study; the EXCLUDER Conformable endoprosThesis foR angulatEd proxiMal nEck anatomy registry).

Journal of vascular surgery·2026
Same author

Side-viewing probe for lesion depth mapping on the left ventricle epicardium with near-infrared spectroscopy.

Scientific reports·2026
Same author

Multimodal PSOCT-NIRS catheter for guided ablation of atrial fibrillation.

Journal of biomedical optics·2026

Related Experiment Video

Updated: Apr 22, 2026

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
07:30

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

7.6K

Capturing structure and function in an embryonic heart with biophotonic tools.

Ganga H Karunamuni1, Shi Gu2, Matthew R Ford2

  • 1Department of Pediatrics, Case Western Reserve University School of Medicine Cleveland, OH, USA.

Frontiers in Physiology
|October 14, 2014
PubMed
Summary

Early cardiac function disturbances can lead to congenital heart defects (CHDs). New biophotonic tools, like optical coherence tomography (OCT), enable detailed study of embryonic heart function, aiding CHD research.

Keywords:
avian modelscardiovascular developmentcongenital heart defectsfetal alcohol syndromeoptical coherence tomographyoptical mappingoptical pacing

More Related Videos

Analysis of Coronary Vessels in Cleared Embryonic Hearts
08:25

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Published on: December 7, 2016

11.5K
Quantitative Whole-mount Immunofluorescence Analysis of Cardiac Progenitor Populations in Mouse Embryos
09:42

Quantitative Whole-mount Immunofluorescence Analysis of Cardiac Progenitor Populations in Mouse Embryos

Published on: October 12, 2017

9.2K

Related Experiment Videos

Last Updated: Apr 22, 2026

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
07:30

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

7.6K
Analysis of Coronary Vessels in Cleared Embryonic Hearts
08:25

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Published on: December 7, 2016

11.5K
Quantitative Whole-mount Immunofluorescence Analysis of Cardiac Progenitor Populations in Mouse Embryos
09:42

Quantitative Whole-mount Immunofluorescence Analysis of Cardiac Progenitor Populations in Mouse Embryos

Published on: October 12, 2017

9.2K

Area of Science:

  • Developmental Biology
  • Cardiovascular Physiology
  • Biomedical Optics

Background:

  • Early embryonic cardiac function is crucial for normal heart development.
  • Congenital heart defects (CHDs) arise from developmental anomalies.
  • Studying early cardiac function is challenging due to limited tools.

Purpose of the Study:

  • To introduce and discuss the application of biophotonic tools for studying embryonic heart development.
  • To highlight the role of optical coherence tomography (OCT) in assessing cardiac function.
  • To explore how functional studies can elucidate CHD etiology.

Main Methods:

  • Development and implementation of biophotonic tools, specifically optical coherence tomography (OCT).
  • Utilizing OCT for detailed structural and functional studies of the embryonic heart.
  • Integrating OCT with optical mapping (OM) and optical pacing (OP) for comprehensive analysis.

Main Results:

  • OCT allows for rapid, quantitative phenotyping of the embryonic heart at multiple developmental stages.
  • Biophotonic tools, including OCT, can study the fragile embryonic heart under physiological conditions.
  • Combined tools reveal biophysical changes impacting mechanotransduction pathways.

Conclusions:

  • Biophotonic tools offer novel insights into the role of cardiovascular function in heart development.
  • Understanding functional changes can improve explanations for the etiology of CHDs.
  • Advances in biophotonic tools are crucial for future research in cardiac development and defects.