Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Longitudinal Studies01:26

Longitudinal Studies

697
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
697
Polygenic Traits01:18

Polygenic Traits

57.9K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
57.9K
Polygenic Traits01:18

Polygenic Traits

7.1K
7.1K
Heritability01:06

Heritability

967
Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
967
Multiple Allele Traits01:49

Multiple Allele Traits

32.3K
The Concept of Multiple Allelism
32.3K
Multiple Allele Traits01:49

Multiple Allele Traits

9.1K
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential DNA Methylation of the Serotonin Receptor Signaling and Glutamatergic Synapse Pathways in Adult Twins Born Preterm.

Genes·2026
Same author

Transcriptome- and Epigenome-Wide Association Studies of Tic Spectrum Disorder in Discordant Monozygotic Twins.

Genes·2026
Same author

25-Hydroxyvitamin D<sub>3</sub> metabolism modulates the effect of variable UV exposure on 25-hydroxyvitamin D<sub>3</sub> plasma concentrations.

Communications medicine·2026
Same author

Differential Epigenetic Regulation of Glutamatergic Synapse Pathway in Adults With Prenatal Exposure to Famine.

The European journal of neuroscience·2025
Same author

Age-Dependent DNA Methylation Variability on the X-Chromosome in Male and Female Twins.

Epigenomes·2024
Same author

Genome-Wide DNA Methylation Profiling as a Prognostic Marker in Pituitary Adenomas-A Pilot Study.

Cancers·2024

Related Experiment Video

Updated: Apr 22, 2026

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

5.8K

Power estimation for gene-longevity association analysis using concordant twins.

Qihua Tan1, Jing Hua Zhao2, Torben Kruse3

  • 1Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9B, 5000 Odense C, Denmark ; Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark.

Genetics Research International
|October 14, 2014
PubMed
Summary

Utilizing longevity concordant twin pairs significantly boosts statistical power in genetic association studies. Identical twins offer greater efficiency than fraternal twins for identifying longevity-associated genes.

More Related Videos

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.4K
Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

9.4K

Related Experiment Videos

Last Updated: Apr 22, 2026

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

5.8K
The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.4K
Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

9.4K

Area of Science:

  • Genetics
  • Biostatistics
  • Gerontology

Background:

  • Statistical power is crucial for genetic association studies, especially for complex traits like human longevity.
  • Human longevity is influenced by genetic and environmental factors, posing challenges due to small sample sizes.
  • Twin studies are valuable for genetic research due to inherent genetic relatedness.

Purpose of the Study:

  • To estimate the statistical power of genetic association studies using longevity-concordant twin pairs.
  • To compare the efficiency of different twin types (identical vs. fraternal) for longevity gene discovery.
  • To assess the impact of longevity cutoff ages on required sample sizes.

Main Methods:

  • Computer simulations were employed to model genetic association studies.
  • The study simulated the use of singletons from longevity-concordant twin pairs as cases.
  • Analyses compared power across identical and fraternal twins, and varied longevity cutoff ages (90 vs. 95).

Main Results:

  • Using singletons from longevity-concordant twin pairs as cases markedly increased statistical power compared to sporadic probands.
  • Identical twins concordant for longevity demonstrated higher efficiency, requiring half the sample size of fraternal twins for similar power.
  • A longevity cutoff at age 90 required 2- to 3-fold more samples than a cutoff at age 95.

Conclusions:

  • Longevity-concordant twin pairs are highly valuable and efficient samples for genetic association studies on human longevity.
  • Identical twins provide a more powerful resource than fraternal twins for this research.
  • The choice of longevity cutoff age significantly impacts the required sample size and study power.