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Updated: Apr 22, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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The notch ligand JAGGED1 as a target for anti-tumor therapy

Demin Li1, Massimo Masiero1, Alison H Banham1

  • 1Radcliffe Department of Medicine, Nuffield Division of Clinical Laboratory Sciences, Weatherall Institute of Molecular Medicine, University of Oxford , Oxford , UK.

Frontiers in Oncology
|October 14, 2014
PubMed

Insights

Jagged1 (JAG1) protein is crucial in cancer development by fueling tumor growth and spread. Targeting JAG1 offers a promising therapeutic strategy for various cancers, impacting tumor cells and their environment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • The Notch pathway is a significant target for cancer therapy.
  • Notch ligands, like Jagged1 (JAG1), are attractive therapeutic targets due to specific expression and function.
  • JAG1 overexpression is common in many cancers and influences tumor progression.

Purpose of the Study:

  • To provide an overview of Jagged1 (JAG1) and its biological functions in cancer.
  • To explore the potential of JAG1 as a therapeutic target for cancer treatment.

Main Methods:

  • Literature review and analysis of existing research on JAG1 and Notch signaling in cancer.
  • Examination of JAG1's role in cancer stem cell maintenance, survival, apoptosis, proliferation, and metastasis.
  • Assessment of JAG1's indirect effects on the tumor microenvironment, including vasculature and immune infiltration.

Main Results:

  • JAG1 overexpression is linked to tumor growth, cancer stem cell populations, and metastasis.
  • JAG1 signaling promotes cell survival and inhibits apoptosis.
  • JAG1 influences tumor vasculature and immune cell infiltration, impacting the tumor microenvironment.

Conclusions:

  • Jagged1 (JAG1) plays a multifaceted role in promoting tumor growth and metastasis.
  • Targeting JAG1 presents a viable therapeutic strategy for various cancers.
  • Further research into JAG1-based therapies could lead to novel cancer treatments.
Keywords:
Jagged1Notch pathwayangiogenesiscancer stem cellscancer therapy

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