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Related Experiment Video

Updated: Apr 22, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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[Association between phase angle, PRISM I and sepsis severity].

Zina Maria Almeida de Azevedo1, Dilma Ribeiro Silva, Maria Virgínia P Dutra2

  • 1Instituto Fernandes Figueira, FIOCRUZ.

Revista Brasileira De Terapia Intensiva
|October 14, 2014
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Summary

Low phase angle in pediatric critical patients may indicate a poorer prognosis. This study found that the lowest phase angle values correlated with higher Pediatric Risk of Mortality I scores in critically ill children.

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Area of Science:

  • Biophysics
  • Critical Care Medicine
  • Nutritional Assessment

Context:

  • Phase angle (PA), derived from bioelectrical impedance analysis (BIA), reflects body cell mass and cellular integrity.
  • Low phase angle is linked to increased morbidity and mortality in critically ill patients.
  • Understanding PA's role in pediatric critical care is crucial for prognosis.

Purpose:

  • To investigate the relationship between phase angle and the Pediatric Risk of Mortality I (PRISM I) score.
  • To explore the association between phase angle and sepsis severity in pediatric patients.
  • To determine the prognostic implications of phase angle in the Pediatric Intensive Care Unit (PICU).

Summary:

  • A transversal study in a PICU evaluated 75 pediatric patients, including 68 with sepsis.
  • Phase angle measurements using BIA were analyzed in relation to PRISM I scores, sepsis severity, and multiple organ dysfunction syndromes (MODS).
  • While no significant differences were found across PRISM I or MODS categories, the lowest phase angle values (1.5º-2.2º) were associated with the highest PRISM I scores (>30%).

Impact:

  • Low phase angle values in pediatric critical patients may serve as a prognostic indicator.
  • This finding highlights the potential utility of phase angle in assessing the severity and predicting outcomes for critically ill children, particularly those with sepsis.
  • Further research can explore therapeutic interventions to improve phase angle and patient outcomes.