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Related Experiment Video

Updated: Apr 22, 2026

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Prognostic parameters and spinal metastases: a research study.

Jefferson W Daniel¹, José C E Veiga¹

¹Division of Neurosurgery, Santa Casa de São Paulo - Faculty of Medical Sciences, São Paulo, Brazil.

|October 14, 2014

Summary

This summary is machine-generated.

Pre-operative walking incapacity, special care dependency, and thecal sac contact with spinal tumors are key survival predictors in patients with unknown primary cancer. These factors can guide surgical decisions for better patient outcomes.

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Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

Area of Science:

Oncology
Neurosurgery
Spinal Surgery

Background:

Spinal epidural neoplastic metastasis (SENM) presents a significant challenge, particularly when the primary tumor is unknown.
Accurate prognostic assessment is crucial for determining appropriate treatment strategies, balancing surgical intervention with palliative care.

Purpose of the Study:

To identify pre-operative prognostic factors influencing survival in patients diagnosed with SENM of unknown primary origin.
To provide data that can aid in surgical decision-making for this patient cohort.

Main Methods:

Retrospective chart review of 52 patients who underwent surgery for SENM between 1997 and 2011.
Kaplan-Meier survival analysis and Log-Rank tests were employed to assess survival outcomes.
Prognostic parameters evaluated included pre-operative walking ability, Karnofsky Performance Score, and tumor involvement of the thecal sac.

Main Results:

The median post-operative survival was 70 days, with 73.07% of patients dying within 6 months.
Common primary tumor types included lung cancer, prostate cancer, myeloma, and lymphoma (61.53%).
Pre-operative walking incapacity, special care dependency, and thecal sac contact with metastases were identified as potential prognostic indicators.

Conclusions:

Pre-operative walking incapacity, dependency on special care, and tumor contact with the thecal sac are significant factors for predicting survival in SENM patients with unknown primary tumors.
A post-operative survival of 2-3 months may justify surgical treatment, guiding the balance between aggressive intervention and palliative care.