L-fucose from vitamin C with only acetonide protection
Zilei Liu1, Akihide Yoshihara, Mark R Wormald
1Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford, OX1 3TA, U.K.
Abstract:
Addition of human milk oligosaccharides (HMO) to baby foods may protect infants from disease. As many simple HMOs are fucosylated this is likely to increase the demand for L-fucose as a synthetic building block. Any chemical synthesis must be cheap to compete with a biotechnological process. Acetonide is the only protecting group we have used in this new synthesis of L-fucose from vitamin C in 27% overall yield (purification by recrystallization; no chromatography required in the entire sequence).
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