Related Experiment Video

Updated: Apr 22, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

18.8K

[Red blood cell transfusion in children admitted in a pediatric intensive care unit]

Nelise Luciano Marvulo1, Rossano César Bonatto2, Mário Ferreira Carpi2

  • 1Faculdade de Medicina de Botucatu, UNESP.

Revista Brasileira De Terapia Intensiva
|October 14, 2014
PubMed

Insights

Red blood cell transfusions in critically ill children are guided by restrictive hemoglobin level indications, typically between 7-10 g/dL. A protocol was implemented to improve transfusion practices in the pediatric intensive care unit (PICU).

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Transfusion medicine

Context:

  • Indications for red blood cell transfusion in critically ill children are not well-defined.
  • This study examines transfusion practices in a pediatric intensive care unit (PICU).

Purpose:

  • To describe red blood cell transfusion practices at the PICU of UNESP-Botucatu Medical School.
  • To analyze transfusion indications and patient characteristics in a pediatric intensive care setting.

Summary:

  • A retrospective observational study analyzed 75 critically ill children receiving transfusions in 2003.
  • Anemia (71.4%) and active bleeding (24.7%) were primary indications, with hemoglobin levels often between 7-10 g/dL.
  • Increased respiratory rate, paleness, and hypotension were common pre-transfusion findings; metabolic acidosis and hypoxemia were also frequent.

Impact:

  • The study found that red blood cell transfusions are prescribed restrictively in the PICU.
  • Implementation of a protocol aims to optimize transfusion guidelines and documentation.
  • Highlights the need for clear protocols in pediatric transfusion medicine.
Abstract

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.4K
Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics04:11

Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics

Published on: March 15, 2024

1.8K

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
12.4K
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.9K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.9K
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
2.2K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
395
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
972