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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Controlling the spread of vancomycin-resistant enterococci. Is active screening worthwhile?

H Humphreys1

  • 1Department of Clinical Microbiology, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.

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|October 15, 2014
PubMed
Summary

Active screening for vancomycin-resistant enterococci (VRE) helps prevent infections in high-risk patients. This strategy identifies carriers, reduces VRE colonization, and may offer cost savings, though further research is needed.

Keywords:
ColonizationMolecular methodsRisk groupsScreeningSelective mediaVancomycin-resistant enterococci

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Area of Science:

  • Infectious Diseases
  • Healthcare Epidemiology
  • Clinical Microbiology

Background:

  • Vancomycin-resistant enterococci (VRE) are a major cause of healthcare-associated infections.
  • Active screening identifies VRE carriage in at-risk patients, aiding prevention.

Purpose of the Study:

  • To review the impact of VRE screening on prevention and control.
  • To assess the cost-effectiveness of VRE screening.
  • To evaluate recent laboratory detection methods for VRE.

Main Methods:

  • Systematic review of English-language studies published since 2000.
  • Inclusion of original reports and relevant guidelines.
  • Analysis of patient groups, screening impact, cost-effectiveness, and laboratory techniques.

Main Results:

  • Identified high-risk patient groups for VRE screening: critical care, hematology/oncology, transplant, chronic dialysis, and long-stay unit admissions.
  • Active screening is linked to reduced VRE colonization and infection rates, with some studies showing cost savings.
  • Selective media improve VRE detection sensitivity and speed; the role of molecular methods requires further investigation.

Conclusions:

  • Active VRE screening contributes to prevention, likely by increasing adherence to control measures like isolation.
  • Further research is needed to refine high-risk group identification, quantify clinical and economic benefits, and optimize laboratory detection methods for diverse populations.