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Related Concept Videos

Genomics02:02

Genomics

35.1K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

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Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Updated: Apr 22, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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AML genomics for the clinician.

Timothy Graubert1, Richard Stone2

  • 1Massachusetts General Hospital Cancer Center, Boston, MA.

Seminars in Hematology
|October 15, 2014
PubMed
Summary

New genomic sequencing technologies offer hope for improving acute myeloid leukemia (AML) treatment. These advanced methods can enhance diagnosis and prognosis, potentially leading to better therapeutic outcomes for AML patients.

Area of Science:

  • Hematology
  • Genomics
  • Oncology

Background:

  • Acute myeloid leukemia (AML) is a complex blood cancer with limited treatment advancements over 30 years.
  • Current AML therapies show poor outcomes, especially in older adults, despite improved supportive care.
  • Genomic insights into AML have improved prognosis and therapy selection, but clinical translation remains a challenge.

Purpose of the Study:

  • To discuss the potential of novel genomic technologies in acute myeloid leukemia (AML).
  • To explore how gene panel and whole-exome/genome sequencing can advance AML diagnosis and prognosis.
  • To highlight the prospective impact of these technologies on therapeutic outcomes in AML.

Main Methods:

  • Review of recent advancements in genomic interrogation technologies.

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  • Discussion of gene panel sequencing, whole-exome sequencing, and whole-genome sequencing applications.
  • Analysis of how these technologies can refine AML patient stratification and treatment selection.

    • Main Results:

    • Genomic analysis, including cytogenetics and mutation assessment, aids in prognostication.
    • New sequencing technologies provide in-depth interrogation of individual cancer genomes.
    • These technologies hold promise for more precise diagnosis and personalized therapy in AML.

    Conclusions:

    • Advanced genomic sequencing technologies are poised to revolutionize AML management.
    • Improved diagnostic and prognostic capabilities can lead to better-tailored therapeutic strategies.
    • The integration of comprehensive genomic profiling is crucial for advancing AML patient care and outcomes.