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Seroprevalence of Toxocara spp. in children with atopy

Daliane Faria Grama1, Susana Zevallos Lescano2, Kelem Cristina Pereira Mota1

  • 1Instituto de Ciências Biomédicas, Laboratório de Parasitologia, Universidade Federal de Uberlândia, Minas Gerais, Brazil.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|October 15, 2014
PubMed

Insights

This study found a high prevalence of Toxocara infection in children, but no direct link to atopic diseases. Further investigation into environmental contamination is suggested.

Area of Science:

  • Parasitology
  • Pediatric Allergy
  • Epidemiology

Background:

  • Toxocara spp. infection is suspected to influence atopic diseases, particularly in pediatric populations.
  • This research examined toxocariasis seroprevalence in atopic children within a specific clinical setting.

Purpose of the Study:

  • To determine the seroprevalence of toxocariasis in atopic children.
  • To explore potential associations between toxocariasis and risk factors in children.

Main Methods:

  • A cross-sectional study involving 173 children (aged 6-15) from November 2011 to March 2013.
  • Clinical examinations, skin-prick tests for atopy, and questionnaires for risk factors were employed.
  • Serum IgG antibodies to Toxocara spp. were quantified using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • Seroprevalence of Toxocara spp. was 19.6% in atopic children and 15% in non-atopic children, without statistical significance.
  • No significant associations were identified between Toxocara infection and risk factors in either group.
  • The study highlights a considerable seroprevalence of Toxocara spp. in the pediatric cohort.

Conclusions:

  • No statistical link was established between human toxocariasis and atopy in this study.
  • The high seroprevalence suggests potential environmental contamination with Toxocara eggs in the study area.
  • Further research into environmental factors is warranted to understand the transmission dynamics.
Abstract

Keywords:
Atopic childrenELISASeroprevalenceToxocariasis

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