Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.5K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.5K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

1.2K
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
1.2K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

946
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
946
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

11
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
11
Mitochondria01:37

Mitochondria

13.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.3K
Mitochondrial Membranes01:45

Mitochondrial Membranes

11.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive rehabilitation among long COVID patients using vibratory and auditory treatment (VAT) is linked to BDNF.

Frontiers in cognition·2026
Same author

A multimodal evaluation of transcranial photobiomodulation in mild cognitive impairment: Cognitive, metabolic, and neuroimaging outcomes of a pilot randomized controlled trial.

Journal of Alzheimer's disease : JAD·2026
Same author

The Estrogen-Mitochondria Axis in Bipolar Disorder: From Fluctuating Hormones to Failing Bioenergetics.

Biological psychiatry global open science·2026
Same author

Pilot Trial of Adjunctive Curcumin for Treatment-Resistant Bipolar Depression in Youth: Focus on Inflammation and Oxidative Stress.

Journal of child and adolescent psychopharmacology·2026
Same author

Immunogenetic Variants in Major Mental and Neurodevelopmental Disorders.

Biological psychiatry·2026
Same author

Itaconate supplementation leads to improvement in donor lung function after extended hypothermic preservation.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

A novel pathogenic synonymous DHCR7 variant unveiled by aberrant splicing in Smith-Lemli-Opitz syndrome.

Human genetics·2026
Same journal

Blending borders: reconstructing the genetic history of the Sindhi population.

Human genetics·2026
Same journal

Within-sibling attenuation of polygenic risk score accuracy: investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank.

Human genetics·2026
Same journal

Long-read genome sequencing resolves a de novo complex 18q12.1q21.2 triplication causing partial tetrasomy and reveals its underlying mechanism.

Human genetics·2026
Same journal

A genetic variant of adenylate cyclase 7 associated with ulcerative colitis shows impaired function and G-protein-coupled receptor signaling.

Human genetics·2026
Same journal

AI in variant analysis: fast track to genetic diagnoses.

Human genetics·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

1.9K

Mitochondrial dysfunction in schizophrenia: an evolutionary perspective.

Vanessa F Gonçalves1, Ana C Andreazza, James L Kennedy

  • 1Centre for Addiction and Mental Health, 1st Floor, Room: 123, 250 College Street, Clarke Site, Toronto, ON, M5T 1R8, Canada, vanessa.goncalves@camh.ca.

Human Genetics
|October 15, 2014
PubMed
Summary
This summary is machine-generated.

Schizophrenia (SCZ) involves disrupted brain energy metabolism, potentially linked to human brain evolution and mitochondrial function. This review explores SCZ

More Related Videos

Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

6.3K
Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
07:47

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

13.7K

Related Experiment Videos

Last Updated: Apr 22, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

1.9K
Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

6.3K
Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
07:47

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

13.7K

Area of Science:

  • Neuroscience
  • Evolutionary Biology
  • Psychiatry

Background:

  • Schizophrenia (SCZ) is a severe psychiatric disorder affecting 0.4% of the population.
  • Energy metabolism disturbances are implicated in SCZ pathogenesis.
  • Human brain evolution involved increased energy demands and mitochondrial system co-evolution.

Purpose of the Study:

  • To review current knowledge on human brain evolution pathways and SCZ origins.
  • To discuss the role of mitochondria in brain energy metabolism and SCZ.
  • To explore how understanding SCZ in evolutionary context can elucidate its pathophysiology.

Main Methods:

  • Literature review of existing research on SCZ, brain evolution, and mitochondrial function.
  • Synthesis of theories regarding the evolutionary origins of SCZ.
  • Discussion of the role of mitochondrial dysfunction in SCZ.

Main Results:

  • Evidence suggests a link between SCZ etiopathogenesis and human brain evolution.
  • Mitochondria are critical for brain energy homeostasis and appear disrupted in SCZ.
  • Evolutionary perspectives offer new insights into SCZ pathophysiology.

Conclusions:

  • Mitochondrial dysfunction is a key factor in SCZ, potentially rooted in evolutionary pressures.
  • Viewing SCZ through the lens of human brain evolution provides a novel framework for understanding the disorder.
  • Further research into evolutionary aspects of mitochondrial function may reveal new therapeutic targets for SCZ.