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Updated: Apr 22, 2026

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
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Tissue factor and atherothrombosis.

D Saha, Saha S, E G Sergeeva

  • 1I.P. Pavlov 1st Saint Petersburg State Medical University, Lev Tolstoy Street 6/8, Staint- Petersburg, 197022, Russia. ele195738@yandex.ru.

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|October 15, 2014
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Summary
This summary is machine-generated.

Tissue factor (TF) initiates blood clotting and drives atherosclerosis. Inhibiting TF may prevent cardiovascular events like heart attack and stroke by reducing thrombus formation.

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Area of Science:

  • Cardiovascular Biology
  • Hemostasis and Thrombosis
  • Atherosclerosis Pathogenesis

Background:

  • Tissue factor (TF) initiates the extrinsic coagulation pathway, crucial for thrombin generation.
  • TF is expressed in subendothelial tissues and can be induced on endothelial cells by inflammatory mediators.
  • TF plays a critical role in atherosclerotic plaque thrombogenicity and cardiovascular death prediction.

Purpose of the Study:

  • To review the role of tissue factor in atherothrombosis.
  • To explore TF as a therapeutic target for cardiovascular diseases.

Main Methods:

  • Literature review of TF's role in coagulation and atherosclerosis.
  • Analysis of TF expression in atherosclerotic plaques.
  • Discussion of potential TF-targeted therapies.

Main Results:

  • TF is a key determinant of atherosclerotic plaque thrombogenicity.
  • Elevated TF levels in plaques correlate with unstable angina.
  • Baseline plasma TF activity predicts cardiovascular death in myocardial infarction patients.

Conclusions:

  • TF is central to atherothrombosis, particularly after plaque rupture.
  • Inhibiting TF activity offers a promising therapeutic strategy for cardiovascular diseases.
  • Targeting the TF pathway could reduce the incidence of myocardial infarction, stroke, and sudden death.