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PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update

Annu Makker1, Madhu Mati Goel2, Abbas Ali Mahdi2

  • 1Post-Graduate Department of PathologyDepartment of BiochemistryKing George's Medical University, Lucknow 226003, Uttar Pradesh, India annumakker@gmail.com.

Journal of Molecular Endocrinology
|October 15, 2014
PubMed

Insights

Key signaling pathways, PI3K/PTEN/Akt and TSC/mTOR, regulate ovarian function. Their dysregulation is linked to female infertility, impacting oogenesis and folliculogenesis.

Area of Science:

  • Reproductive Biology
  • Molecular Endocrinology

Background:

  • Ovarian function relies on precise regulation of oogenesis and folliculogenesis.
  • Defects in these processes are a major cause of female reproductive deficiency.
  • The PI3K/PTEN/Akt and TSC/mTOR signaling pathways are implicated in ovarian cell regulation.

Purpose of the Study:

  • To review the role of PI3K/PTEN/Akt and TSC/mTOR pathways in mammalian oogenesis and folliculogenesis.
  • To explore the association between these pathways and female infertility.

Main Methods:

  • Literature review of existing research on PI3K/PTEN/Akt and TSC/mTOR signaling in ovarian function.
  • Analysis of studies linking pathway dysregulation to infertility.

Main Results:

  • These pathways are crucial for primordial follicle dynamics, granulosa cell development, and oocyte maturation.
  • Dysfunction of these pathways correlates with impaired follicular development and ovulation.
  • Aberrant signaling contributes to infertility by disrupting key reproductive events.

Conclusions:

  • The PI3K/PTEN/Akt and TSC/mTOR pathways are essential for normal ovarian function.
  • Understanding these pathways offers insights into the molecular basis of female infertility.
  • Targeting these pathways may hold potential for future infertility treatments.
Keywords:
PI3K/PTEN/Akt and TSC/mTOR pathwaysfolliculogenesisinfertilityoogenesisovarian function

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