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Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus

A Espinel-Ingroff1, A Chowdhary2, G M Gonzalez3

  • 1VCU Medical Center, Richmond, Virginia, USA avingrof@vcu.edu.

Antimicrobial Agents and Chemotherapy
|October 15, 2014
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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