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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Emerging techniques and technologies in brain tumor imaging.

Benjamin M Ellingson1, Martin Bendszus1, A Gregory Sorensen1

  • 1Department of Radiological Sciences, David Geffen School of Medicine at University of California, Los Angeles, California (B.M.E., W.B.P.); Department of Biomedical Physics, David Geffen School of Medicine at University of California, Los Angeles, California (B.M.E.); Department of Bioengineering, Henry Samueli School of Engineering and Applied Science at University of California, Los Angeles, California (B.M.E.); Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, California (B.M.E.); UCLA Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, California (B.M.E.); Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany (M.B.); Siemens Healthcare, Erlangen, Germany (A.G.S.).

Neuro-Oncology
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Standardized imaging and volumetric analysis improve brain tumor response detection in clinical trials. Advanced techniques like diffusion MRI and amino acid PET show promise for more accurate treatment monitoring.

Keywords:
MRIPETT1 subtractionbrain tumorsdiffusion MRIimaging biomarkerperfusion MRIresponse assessment

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Area of Science:

  • Neuroimaging
  • Oncology
  • Radiology

Background:

  • Accurate assessment of brain tumor treatment response is crucial for clinical trial success.
  • Multicenter clinical trials require standardized and reliable imaging methods for evaluating treatment efficacy.

Purpose of the Study:

  • To review current and emerging imaging techniques for detecting brain tumor treatment response in multicenter clinical trials.
  • To highlight the importance of standardization in image acquisition and analysis for improved quantification.

Main Methods:

  • Review of existing imaging technologies and their application in clinical trials.
  • Discussion of potential advancements including diffusion MRI, perfusion MRI, and amino acid PET.
  • Exploration of novel techniques like 2(3)Na MRI and CEST imaging.

Main Results:

  • Standardized image acquisition, volumetric measurements, and subtraction maps enhance tumor visualization and quantification.
  • Diffusion MRI, perfusion MRI, and amino acid PET offer potential for improved detection of treatment response.
  • Emerging technologies like 2(3)Na MRI and CEST imaging are under investigation for quantitative assessment.

Conclusions:

  • Standardization of current imaging techniques is vital for reliable assessment of brain tumor treatment response.
  • Advanced and novel imaging technologies hold significant promise for enhancing quantitative evaluation in clinical trials.
  • Continued research and development are necessary to fully realize the potential of these techniques in neuro-oncology.