Evaluation of platelet distribution width and mean platelet volume in patients with carotid artery stenosis
Gürhan Adam1, Erdem Kocak2, Adile Özkan3
1Department of Radiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey gurhanadam@hotmail.com.
Insights
Platelet distribution width (PDW) correlates with carotid artery stenosis (CS) severity, unlike mean platelet volume (MPV). PDW may serve as a valuable biomarker for assessing CS progression.
Area of Science:
- Cardiovascular Research
- Hematology
- Biomarker Discovery
Background:
- Atherosclerosis pathogenesis involves platelet activation, often indicated by elevated mean platelet volume (MPV) and platelet distribution width (PDW).
- The relationship between platelet indices and the severity of carotid artery stenosis (CS) requires further elucidation.
Purpose of the Study:
- To investigate the association between platelet distribution width (PDW) and mean platelet volume (MPV) with the degree of carotid artery stenosis (CS).
Main Methods:
- Retrospective analysis of demographic and clinical data from 229 patients categorized by North American Symptomatic Carotid Endarterectomy Trial criteria.
- Correlation analysis was employed to assess the relationship between PDW, MPV, and CS severity.
Main Results:
- A significant positive correlation was observed between platelet distribution width (PDW) and the degree of carotid artery stenosis (CS).
- No significant correlation was found between mean platelet volume (MPV) and the degree of CS.
- PDW and low-density lipoprotein cholesterol emerged as independent predictors of CS severity.
Conclusions:
- Platelet distribution width (PDW), not mean platelet volume (MPV), is associated with the degree of carotid artery stenosis.
- PDW shows potential as a useful biomarker for assessing carotid artery stenosis.
- Further research is needed to determine the clinical utility of targeting PDW in managing CS.
Abstract:
Platelets contribute to the pathogenesis of atherosclerosis. Platelet activation has been linked with increased mean platelet volume (MPV) and platelet distribution width (PDW). We investigated the association between PDW, MPW, and the degree of carotid artery stenosis (CS). Patients (n = 229) were divided into 3 groups according to the North American Symptomatic Carotid Endarterectomy Trial criteria. Demographic and clinical features were collected retrospectively. Correlation analysis showed a positive association between PDW and the degree of CS. However, there was no significant correlation between CS and MPV. Moreover, we observed that PDW and low-density lipoprotein cholesterol were independent predictors of the degree of CS. This study showed that PDW, not MPV, is related to the degree of CS. Platelet distribution width could be a useful biomarker for CS. Whether targeting PDW will be of clinical benefit remains to be established.
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