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Synthetic studies towards Zetekitoxin AB: preparation of 4,5-epi-11-hydroxy-saxitoxinol

Aaron D Pearson1, Robert M Williams1

  • 1Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.

Tetrahedron
|October 15, 2014
PubMed

Abstract:

A concise synthesis of 4,5-epi-11-hydroxy-saxitoxinol utilizing D-ribose to direct an asymmetric Mannich reaction. This approach allows many modes of reactivity, which can be used to access various analogs of saxitoxin.

Keywords:
Diamino acidMannich reactionSaxitoxinSodium channelZetekitoxin AB

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