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S100A12 expression in patients with primary biliary cirrhosis
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing , China .
Immunological Investigations
|October 15, 2014
Summary
S100 calcium binding protein A12 (S100A12) is elevated in primary biliary cirrhosis (PBC) patients, indicating its role in liver damage. This protein may serve as a marker for assessing PBC activity.
Area of Science:
- Immunology
- Hepatology
- Biochemistry
Background:
- S100 calcium binding protein A12 (S100A12) is implicated as a pro-inflammatory factor in non-infectious inflammatory diseases.
- The specific role of S100A12 in the pathogenesis of primary biliary cirrhosis (PBC) remains unelucidated.
Purpose of the Study:
- To investigate the involvement of S100A12 in the inflammatory process of primary biliary cirrhosis (PBC).
- To assess the potential of S100A12 as a biomarker for PBC activity.
Main Methods:
- Quantitative real-time PCR (qRT-PCR) was used to measure S100A12 mRNA levels in peripheral blood mononuclear cells (PBMCs) from 66 PBC patients, 62 healthy controls (HC), and 55 chronic hepatitis B (CHB) patients.
- Enzyme-linked immunosorbent assay (ELISA) was employed to determine S100A12 serum concentrations in 34 PBC patients.
Main Results:
- S100A12 mRNA levels in PBMCs were significantly higher in PBC patients compared to both HC (p < 0.01) and CHB patients (p < 0.01).
- Elevated S100A12 mRNA levels in PBMCs and S100A12 protein levels in serum showed a positive correlation with biochemical markers of bile duct and hepatocyte damage.
Conclusions:
- S100A12 may contribute to biliary epithelial cell and hepatocyte damage in PBC.
- S100A12 expression analysis could serve as a valuable surrogate marker for evaluating PBC disease activity.
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