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Related Concept Videos

Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Related Experiment Video

Updated: Apr 22, 2026

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
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Does antibody binding to diverse antigens predict future infection?

J P Owen1, J L Waite, K Z Holden

  • 1Department of Entomology, Washington State University, Pullman, WA, USA.

Parasite Immunology
|October 15, 2014
PubMed
Summary

Host antibody binding to diverse antigens predicts parasite fitness, even unrelated ones. This immune response increases post-infection, suggesting broader protective roles in host-parasite interactions.

Keywords:
ELISAapicomplexanavianimmunoglobulininnate immunityparasite

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Area of Science:

  • Immunology
  • Parasitology
  • Veterinary Science

Background:

  • Host immune responses are crucial in managing parasitic infections.
  • Understanding diverse antigen binding can reveal novel host-parasite interaction mechanisms.

Purpose of the Study:

  • To investigate if pre-infection IgY (immunoglobulin Y) antigen binding predicts parasite fitness.
  • To determine if antigen binding changes following infection with parasites.

Main Methods:

  • Enzyme-linked immunosorbent assays (ELISAs) and immunoblots were employed.
  • Tested IgY binding against extracts from pigeon parasites and nonparasitic molecules.
  • Used captive-bred rock pigeons challenged with blood-feeding flies and a protozoan parasite.

Main Results:

  • Binding to specific parasite and bacterial extracts predicted fly fitness.
  • Binding to various extracts predicted protozoan parasite infection levels.
  • Antigen binding increased across all tested extracts post-infection, indicating a broad immune response.

Conclusions:

  • Host antibody binding to diverse antigens, not just parasite-specific ones, predicts parasite fitness.
  • Innate immunoglobulin binding to parasite-associated molecular markers occurs.
  • These findings have significant implications for understanding host-parasite immunological interactions.