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5-Aza-CdR delivers a gene body blow
Sivakanthan Kasinathan1, Steven Henikoff2
1Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA 98195, USA; Molecular & Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA.
Cancer Cell
|October 15, 2014
Abstract
None:
In this issue of Cancer Cell, Yang et al. describe a causal relationship between gene body methylation and gene expression and a role for genic methylation in response to clinical DNA methylation inhibitors, which suggests that the mechanism of action of these inhibitors includes gene body hypomethylation-induced downregulation of cancer-associated genes.