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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Related Experiment Video

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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NOTch just a bladder control problem.

Keli Xu1, Darius J Bägli2, Sean E Egan3

  • 1Tumor Cell Biology Program, Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Cancer Cell
|October 15, 2014
PubMed
Summary

Human bladder cancers with faulty Notch signaling show basal differentiation due to elevated MAPK pathway activation. Loss of Notch-mediated DUSP transcription contributes to this pathway dysregulation.

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Notch signaling is crucial for cell differentiation and development.
  • Dysregulation of signaling pathways is a hallmark of cancer.
  • Specific alterations in Notch signaling have been implicated in various cancers.

Purpose of the Study:

  • To investigate the role of Notch signaling pathway alterations in human bladder cancers.
  • To understand the downstream consequences of impaired Notch signaling in bladder tumor development.
  • To explore the relationship between Notch signaling status and tumor differentiation.

Main Methods:

  • Analysis of genetic alterations in Notch pathway components in bladder cancer samples.
  • Assessment of MAPK pathway activation levels.
  • Evaluation of DUSP gene expression.
  • Correlation of molecular findings with tumor differentiation markers.

Main Results:

  • Human bladder cancers frequently exhibit deletions and point mutations in Notch signaling genes.
  • Impaired Notch signaling leads to loss of DUSP transcription.
  • This loss results in elevated MAPK pathway activation.
  • Bladder tumors with defective Notch signaling display basal differentiation characteristics.

Conclusions:

  • Alterations in Notch signaling are common in bladder cancer.
  • Impaired Notch signaling contributes to tumor pathogenesis through MAPK pathway activation.
  • Notch signaling status is linked to the basal differentiation phenotype in bladder tumors.