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Successful treatment of HIV-1 infection increases the expression of a novel, short transcript for IL-18 receptor α

Milena Nasi1, Silvia Alboni, Marcello Pinti

  • 1*Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy; †Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy; and ‡Infectious Diseases Clinics, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.

Journal of Acquired Immune Deficiency Syndromes (1999)
|October 15, 2014
PubMed

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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