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Updated: Apr 22, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Gestational diabetes mellitus management with oral hypoglycemic agents
Rachel J Ryu1, Karen E Hays1, Mary F Hebert2
1Department of Pharmacy, University of Washington, 1959 NE Pacific St, H-375 Health Sciences Center, Box 357630, Seattle, WA 98195-7630.
Abstract:
Oral hypoglycemic agents such as glyburide (second-generation sulfonylurea) and metformin (biguanide) are attractive alternatives to insulin due to lower cost, ease of administration, and better patient adherence. The majority of evidence from retrospective and prospective studies suggests comparable efficacy and safety of oral hypoglycemic agents such as glyburide and metformin as compared to insulin when used in the treatment of women with gestational diabetes mellitus (GDM). Glyburide and metformin have altered pharmacokinetics during pregnancy and both agents cross the placenta. In this article, we review the efficacy, safety, and dosage of oral hypoglycemic agents for the treatment of gestational diabetes mellitus. Additional research is needed to evaluate optimal dosage for glyburide and metformin during pregnancy. Comparative studies evaluating the effects of glyburide and metformin on long-term maternal and fetal outcomes are also needed.
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