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Plerixafor: what we still have to learn

Francesco Lanza1, Angelo Gardellini, Daniele Laszlo

  • 1Hematology Institute, Hospital of Cremona , Cremona , Italy.

Expert Opinion on Biological Therapy
|October 16, 2014
PubMed

Plerixafor, a hematopoietic stem cell mobilizer, is indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. Current evidence suggests that the addition of plerixafor with chemotherapy plus G-CSF is safe and effective in the large majority of the patients with low blood CD34(+) cell count after mobilization and/or poor yield after the first collection. Nevertheless, there are several questions strongly debated, and in this paper, we would like to identify areas of possible future use and development of the drug.

Keywords:
autologous transplantationmobilizationperipheral blood stem cellsplerixafor

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