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Related Experiment Video

Updated: Apr 22, 2026

Measuring Attentional Biases for Threat in Children and Adults
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GRIN2B predicts attention problems among disadvantaged children.

Valentina Riva1, Marco Battaglia, Maria Nobile

  • 1Child Psychopathology Unit, Scientific Institute 'Eugenio Medea', Don L. Monza 20, Bosisio Parini (LC), Italy.

European Child & Adolescent Psychiatry
|October 16, 2014
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Summary

Genetic variants in GRIN2B may predict attention problems in children facing low socioeconomic status (SES) and other adversities. This finding could identify at-risk children for targeted interventions.

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Area of Science:

  • Neuroscience
  • Genetics
  • Child Psychology

Background:

  • Childhood adversities and GRIN2B gene variants are independently linked to behavioral and cognitive issues.
  • Many children exposed to adversity exhibit positive long-term outcomes, suggesting protective factors or gene-environment interactions.

Purpose of the Study:

  • To investigate if GRIN2B gene variants interact with adversities to predict negative cognitive and behavioral outcomes in children.
  • To identify specific GRIN2B polymorphisms and environmental factors that confer risk for impaired development.

Main Methods:

  • Genotyped 6 single nucleotide polymorphisms (SNPs) of GRIN2B in 625 children (aged 6-11).
  • Assessed cognitive abilities and parent-rated behavioral problems.
  • Examined interactions between GRIN2B variants and adversities (low SES, preterm birth, maternal smoking, no breastfeeding).

Main Results:

  • A significant interaction between the rs2268119 GRIN2B variant and low socioeconomic status (SES) affected behavior.
  • Children with specific rs2268119 genotypes (A/T or T/T) and low SES showed increased attention problems.
  • This interaction was not replicated in an independent sample.

Conclusions:

  • GRIN2B variants may predict attention deficits in children experiencing low SES.
  • Findings suggest a potential genetic predisposition to adverse outcomes under specific environmental conditions.
  • Further replication is needed to confirm these results and inform risk identification and intervention strategies.