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Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels.

Ki Wan Bong1, Jiseok Lee, Patrick S Doyle

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. pdoyle@mit.edu.

Lab on a Chip
|October 16, 2014
PubMed
Summary
This summary is machine-generated.

Perfluoropolyether (PFPE) elastomers enable Stop Flow Lithography (SFL) with organic solvents, expanding particle synthesis capabilities beyond traditional polydimethylsiloxane (PDMS) limitations. This advancement allows for novel material applications in microfluidics and beyond.

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Area of Science:

  • Microfluidics
  • Materials Science
  • Particle Synthesis

Background:

  • Stop Flow Lithography (SFL) is a microfluidic technique for creating anisotropic multifunctional particles.
  • Polydimethylsiloxane (PDMS) is commonly used for SFL devices due to its properties but is incompatible with organic solvents.
  • This incompatibility limits the range of materials that can be synthesized using SFL.

Purpose of the Study:

  • To introduce perfluoropolyether (PFPE) as an alternative elastomer for SFL microfluidic channels.
  • To demonstrate the feasibility of SFL using PFPE-based devices with oxygen lubrication layers.
  • To assess the performance of PFPE devices compared to traditional PDMS devices.

Main Methods:

  • Fabrication of PFPE microfluidic devices using soft lithography.
  • Synthesis of anisotropic multifunctional particles using SFL in PFPE channels.
  • Benchmarking PFPE device performance against PDMS devices under identical SFL conditions.

Main Results:

  • Successful demonstration of SFL in non-PDMS (PFPE) microfluidic channels with oxygen lubrication.
  • PFPE devices produced particles with dimensions comparable to those from PDMS devices (difference < 1 micron).
  • PFPE's chemical resistance to organic solvents significantly broadens the scope of precursor materials for SFL.

Conclusions:

  • PFPE is a viable alternative to PDMS for SFL microfluidic devices, offering enhanced material compatibility.
  • The use of PFPE in SFL overcomes the limitations imposed by PDMS's poor organic solvent resistance.
  • This development expands the potential applications of SFL in synthesizing novel materials for MEMS and biomedical engineering.