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Updated: Apr 22, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
[Standardization of weaning of the mechanical ventilation in a Intensive Care Unit: results afterwards one year]
Luiz Rogério de Carvalho Oliveira1, Anderson José1, Elaine Cristina Polleti Dias1
1Santa Casa de São Paulo.
Background And Objectives:
The weaning of mechanical ventilation is the process of transition from mechanical ventilation to spontaneous. The actual practice weaning reveals that the empirism is insufficient and inadequate. On the other side, the standardization of the weaning provides best conductions in the process. The objective of this study was to evaluate the effects of the application of a weaning protocol in an intensive care unit.
Method:
It was included in this study all the patients in program of liberation from the mechanical ventilation, in which the evolution of the weaning was followed by the utilization of a pre-establish protocol and publicated by the service.
Results:
It was studied 127 patients. In 91% (115) of the patients we had success in the weaning and unsuccess in 9% (12). The non-invasive ventilation after the extubation was utilized in 19% (24) of them. None obit was observed. Comparing the group of the patients that had success with the failed group, there were no statistically significant variations observed in sex (p = 0.96), APACHE II (19.5 versus 18.6 p = 0.75), risk of obit (29% versus 22% p = 0.54), MIP (38 versus 32 cmH2O p = 0.17), duration of mechanical ventilation (6 versus 7 days p = 0.70), PaO2/FiO2 relation (324 versus 312 p = 0.83), weaning modality (PSV or T Tube p = 0.29). There were statistically significant variations observed in rapid shallow respiratory index (59 versus 77 p = 0.02) and duration of the weaning (1 versus 30 hours p < 0.001).
Conclusions:
The weaning of the ventilation realized following the standardization brought improvement in its conduction, maintaining the high success index with low mortality.
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