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Updated: Apr 22, 2026
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Red blood cell alloimmunization in multitransfused patients in a tertiary care center in Western India
Joseph Philip1, Amit Kumar Biswas2, Sumathi Hiregoudar2
1Department of Immunohematology and Blood Transfusion, Armed Forces Medical College, Pune, Maharashtra, India addressed.eoj_in@yahoo.com.
Objective:
To investigate the seroprevalence and specificity of red blood cell (RBC) antibodies in multitransfused patients, in whom the risk of alloimmunization is especially high.
Methods:
We conducted a retrospective study on blood specimens from 200 multitransfused patients. We evaluated all specimens for alloimmunization using various immunohematological tests via the column agglutination technique.
Results:
The overall prevalence of RBC alloantibodies was 5.5%. Of the 11 specific types of alloantibodies identified, most (72.7%) belonged to the Rh blood group system, followed by the S, M, and Lewis blood group systems (9.1% each).
Conclusion:
Most alloantibodies were of the Rh blood group specificity. To improve the quality of blood supplied, especially to patients with thalassemia, we recommend that Rh phenotyped, cross-match-compatible blood should be issued to prevent complications such as acute and delayed hemolytic reactions.
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