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Updated: Apr 22, 2026
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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
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Ascending thoracic aortic aneurysms protect against myocardial infarctions
Katherine Chau1, John A Elefteriades1
1Aortic Institute at Yale-New Haven, Yale University, School of Medicine, New Haven, Connecticut.
Summary
Ascending thoracic aortic aneurysms (TAAs) appear to protect against myocardial infarction (MI). This study found a significantly lower prevalence of MI in patients with ascending TAAs compared to controls.
Area of Science:
- Cardiovascular Medicine
- Atherosclerosis Research
Background:
- Increasing evidence suggests thoracic aortic aneurysms (TAAs) may offer protection against atherosclerosis.
- The relationship between ascending TAAs and clinical atherosclerosis endpoints like stroke or peripheral arterial disease remains understudied.
Purpose of the Study:
- To investigate the association between ascending TAAs and myocardial infarction (MI), a key clinical endpoint of atherosclerosis.
- To compare the prevalence of coronary artery disease (CAD) and MI in patients with and without ascending TAAs.
Main Methods:
- A comparative study involving 487 patients who underwent surgical repair for ascending TAAs and 500 control patients without ascending TAAs.
- Multivariate binary logistic regression analysis was employed to assess the odds of MI in relation to ascending TAAs and other MI risk factors.
Main Results:
- The ascending TAA group exhibited a significantly lower prevalence of both CAD and MI compared to the control group.
- While traditional MI risk factors increased the odds of MI (OR > 1), ascending TAAs were associated with a significantly reduced odds ratio for MI (OR = 0.05).
Conclusions:
- Ascending TAAs demonstrate a protective effect against myocardial infarction.
- These findings support the hypothesis that ascending TAAs confer protection against the development of atherosclerotic disease.
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