Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

3.8K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
3.8K
Ovarian Cycle01:27

Ovarian Cycle

5.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
5.2K
Proliferative Phase01:20

Proliferative Phase

1.9K
The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
1.9K
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

5.0K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
5.0K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

2.3K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
2.3K
Secretory Phase01:19

Secretory Phase

2.8K
The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The gendered "stathetic" body: a scientifically informed philosophical approach to corporality.

History and philosophy of the life sciences·2026
Same author

Spinal cord reactive-antibodies identified by serological antigen selection show prognostic value in traumatic spinal cord injury patients.

Neurobiology of disease·2026
Same author

Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinflammation and improves locomotor outcome following spinal cord injury.

Neuroscience·2025
Same author

Spinal cord injury induces transient activation of hepatic stellate cells in rat liver.

Scientific reports·2025
Same author

The phytoestrogen genistein improves hippocampal neurogenesis and cognitive impairment and decreases neuroinflammation in an animal model of metabolic syndrome.

Journal of neuroendocrinology·2024
Same author

Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, B.C., Canada.

Canadian journal of surgery. Journal canadien de chirurgie·2024
Same journal

Corrigendum: Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.

Neural regeneration research·2026
Same journal

Injury and repair in limb deformities associated with peripheral neuropathy: Visualization analyses of research trends and hotspots.

Neural regeneration research·2026
Same journal

Circulating exosomes convey the cognitive benefits of Tai Chi: The role of miR-625-5p in prefrontal remodeling and therapeutic potential.

Neural regeneration research·2026
Same journal

Induced neural stem cells in neuroregeneration: Progress and clinical prospects.

Neural regeneration research·2026
Same journal

Locus coeruleus-norepinephrine system dysfunction: A new concept in cognitive aging and neurodegenerative diseases.

Neural regeneration research·2026
Same journal

The casual explanations of non-coding risk variants in Alzheimer's disease: From single mutation to lipid dysregulation.

Neural regeneration research·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

2.5K

Give progesterone a chance.

Florencia Labombarda1, Daniel Garcia-Ovejero2

  • 1Laboratory of Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine CONICET, Vuelta de Obligado 2490, Buenos Aires, Argentina ; Departament of Human Biochemistry, School of Medicine, Buenos Aires University, Paraguay 2155, Buenos Aires, Argentina.

Neural Regeneration Research
|October 16, 2014
PubMed
Summary
This summary is machine-generated.

Progesterone shows promise for treating spinal cord injury. This steroid hormone reduces lesion size, preserves white matter, and improves motor function recovery in preclinical models.

Keywords:
myelinneuroprotectionprogesteronespinal cord injurytrauma

More Related Videos

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians
04:37

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Published on: May 12, 2019

17.0K
Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

15.7K

Related Experiment Videos

Last Updated: Apr 22, 2026

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

2.5K
Reproductive Techniques for Ovarian Monitoring and Control in Amphibians
04:37

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Published on: May 12, 2019

17.0K
Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

15.7K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Regenerative Medicine

Background:

  • Currently, no standard pharmacological treatments exist for spinal cord injury (SCI).
  • Progesterone, a neurosteroid hormone, has demonstrated therapeutic potential in traumatic brain injury (TBI) models, advancing to Phase II clinical trials.
  • Pre-existing research indicates progesterone possesses anti-inflammatory, neuroprotective, and promyelinating properties relevant to SCI.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of progesterone in a clinically relevant model of spinal cord lesion.
  • To investigate progesterone's effects on lesion pathology and functional recovery after SCI.

Main Methods:

  • Utilized a clinically relevant model of spinal cord lesion.
  • Administered progesterone and assessed its impact on lesion volume, white matter integrity, and locomotor recovery.

Main Results:

  • Progesterone treatment significantly diminished lesion size.
  • White matter integrity was preserved in progesterone-treated subjects.
  • Significant improvements in locomotor recovery were observed following progesterone administration.

Conclusions:

  • Progesterone demonstrates significant therapeutic potential for spinal cord injury.
  • Its demonstrated benefits in reducing lesion size, preserving neural tissue, and enhancing functional recovery warrant further investigation as a SCI treatment.