Brazilian Registry of Bone Biopsy (REBRABO): design, data elements and methodology

Area of Science:

• Nephrology
• Pathology
• Epidemiology

Background:

• Mineral bone disorder (MBD) significantly impacts morbidity and mortality in chronic kidney disease (CKD) patients.
• Limited data exists on MBD prevalence, treatment effects, and outcomes like fractures, hospitalization, cardiovascular disease, and mortality in CKD.
• National data registries are essential for understanding the epidemiology of CKD-MBD.

Purpose of the Study:

• To describe the design, data elements, and methodology of the Brazilian Registry of Bone Biopsy (REBRABO).
• To establish a national registry for collecting comprehensive data on CKD-MBD patients.

Main Methods:

• REBRABO is an online, national, observational, and multicentric registry.
• It is structured in two phases: a retrospective phase (1st) and a prospective phase (2nd).
• Data includes bone histomorphometric analysis, demographics, clinical, and laboratorial information from CKD-MBD patients.

Main Results:

• The first phase of REBRABO will analyze data from January 1986 to December 2013.
• This phase focuses on demographics, clinical, laboratorial, and bone histomorphometric data.
• Initial results are anticipated in early 2015.

Conclusions:

• Further research on CKD-MBD is necessary, especially regarding prevalence and associations with outcomes.
• REBRABO offers a unique platform for retrospective and prospective research on bone biopsy data in CKD-MBD.
• This registry aims to fill critical knowledge gaps in CKD-MBD research.