Diet, inflammation and the brain: commentary on the 2014 named series

This commentary will summarize the manuscripts in the 2014 Named Series, Diet, Inflammation, and the Brain. The series included studies that addressed the effect of dietary manipulations, including high fat diet, caloric restriction, or variations in dietary composition, on immune system endpoints in the brain, including microglial characterizations, changes in immune cell traffic into the brain, and markers of neuronal activation. Additionally, many of the studies assessed behavioral endpoints in parallel, including memory performance, social behavior and sickness behaviors (fever, decreased locomotion). Additionally, studies were included that focused on the converse relationship; the effect of immune system components (e.g., specific cytokines or chemokines) on metabolic and weight-related endpoints. The Named Series included both human and animal studies, as well as a review. Collectively, these studies highlight this growing area of research, which has great potential for identifying new ways to improve human health through diet.