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Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection

Erlangga Yusuf1, Nancy Perrottet, Christina Orasch

  • 11 Infectious Diseases Service, Department of Medicine, Lausanne University Hospital , Lausanne, Switzerland .

Surgical Infections
|October 16, 2014
PubMed
Abstract

Insights

Daptomycin treatment for prosthetic joint infection can cause eosinophilic pneumonia. This side effect may present with mild fever or severe lung symptoms, requiring clinical awareness.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Pharmacology

Background:

  • Daptomycin is increasingly prescribed for prosthetic joint infections (PJI).
  • Eosinophilic pneumonia is a potential adverse effect of daptomycin therapy.
  • This report details two cases of PJI patients experiencing daptomycin-induced eosinophilic pneumonia.

Observation:

  • Two male patients with MRSE-PJI were treated with daptomycin.
  • Patient 1 presented with fever; bronchoalveolar lavage (BAL) showed eosinophils.
  • Patient 2 developed severe respiratory symptoms; BAL and pleural fluid analysis revealed eosinophilia.

Findings:

  • Daptomycin-induced pneumonia can manifest with varied clinical presentations.
  • Symptoms ranged from isolated fever to significant pulmonary distress.
  • Diagnostic confirmation involved identifying eosinophils in respiratory samples.

Implications:

  • Clinicians, especially surgeons, must consider daptomycin-induced pneumonia in patients with PJI.
  • Awareness of this potential adverse effect is crucial for timely diagnosis and management.
  • Prompt recognition can prevent severe respiratory complications associated with daptomycin use.

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