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Published on: March 16, 2017
Gestational trophoblastic tumours: an update for 2014
Fieke E M Froeling1, Michael J Seckl
1Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Imperial College Healthcare NHS Trust and Imperial College London, Fulham Palace Road, London, W6 8RF, UK.
Gestational trophoblastic disease (GTD) encompasses premalignant and malignant conditions. Effective treatments and early detection via human chorionic gonadotrophin markers lead to over 98% survival rates for GTD.
Area of Science:
- Obstetrics and Gynecology
- Oncology
- Reproductive Medicine
Background:
- Gestational trophoblastic disease (GTD) includes hydatidiform mole, invasive mole, choriocarcinoma, placental-site trophoblastic tumour, and epithelioid trophoblastic tumour.
- These conditions range from premalignant to malignant disorders arising from pregnancy-related tissues.
Purpose of the Study:
- To provide a comprehensive overview of gestational trophoblastic disease.
- To discuss recent advancements in the etiology and pathology of GTD.
- To summarize current management strategies for GTD.
Main Methods:
- Literature review focusing on etiology, pathology, and management of GTD.
- Analysis of diagnostic tools, including human chorionic gonadotrophin (hCG) as a tumor marker.
- Synthesis of information on treatment strategies and care centralization.
Main Results:
- GTD encompasses a spectrum of pregnancy-related disorders.
- Human chorionic gonadotrophin (hCG) serves as a highly sensitive tumor marker for GTD.
- Effective chemotherapy and centralized care contribute to excellent survival rates exceeding 98%.
Conclusions:
- Gestational trophoblastic disease management has significantly improved outcomes.
- Early detection and targeted therapies are crucial for high survival rates in GTD.
- Continued research into etiology and pathology will further refine treatment approaches.
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