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Related Experiment Video

Updated: Apr 22, 2026

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
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Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

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Transporting neonates with hypoxic-ischemic encephalopathy utilizing active hypothermia.

M D Weiss1, A Tang2, L Young3

  • 1Department of Pediatrics, University of Florida, Gainesville, FL, USA ShandsCair Flight Program, University of Florida, Gainesville, FL, USA.

Journal of Neonatal-Perinatal Medicine
|October 17, 2014
PubMed
Summary
This summary is machine-generated.

A servo-controlled active hypothermia device effectively cools neonates with hypoxic-ischemic encephalopathy (HIE) during transport. The device rapidly achieves and maintains target temperatures in ambulances, aircraft, and helicopters.

Keywords:
Active hypothermiaencephalopathyhypoxic-ischemicneonatestransport

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Area of Science:

  • Neonatal Intensive Care
  • Thermoregulation
  • Transport Medicine

Background:

  • Hypoxic-ischemic encephalopathy (HIE) is a serious condition in newborns.
  • Therapeutic hypothermia is a standard treatment for HIE.
  • Transporting neonates requiring therapeutic hypothermia presents unique challenges.

Purpose of the Study:

  • To evaluate a servo-controlled active hypothermia device for neonatal transport.
  • To assess the device's efficacy in achieving and maintaining target temperatures during transport.

Main Methods:

  • Retrospective review of neonates treated with therapeutic hypothermia (2009-2013).
  • Analysis of data from a servo-controlled active hypothermia device during ground and air transport.
  • Inclusion of 28 neonates with HIE.

Main Results:

  • The servo-controlled device successfully captured core temperatures in all 28 neonates.
  • All neonates reached target temperatures (33-34 °C) within 33 minutes.
  • Consistent target temperatures (33 ± 0.2 °C) were maintained throughout transport, irrespective of vehicle type.

Conclusions:

  • Servo-controlled hypothermia is effective for rapid temperature attainment and maintenance during neonatal transport.
  • The device ensures stable core temperatures in neonates with HIE during both ground and air transfers.
  • This technology facilitates optimal therapeutic hypothermia management for critically ill neonates on the move.