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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Concurrent primary sclerosing cholangitis and eosinophilic colitis.

Naohiko Gunji1, Kyoko Katakura, Atsushi Takahashi

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|October 17, 2014
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This case report details a rare instance of a 39-year-old man with concurrent primary sclerosing cholangitis (PSC) and eosinophilic colitis. The patient experienced worsening diarrhea and abdominal pain, leading to a new diagnosis alongside his existing liver condition.

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Area of Science:

  • Gastroenterology
  • Hepatology
  • Immunology

Background:

  • Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by bile duct inflammation and fibrosis.
  • Eosinophilic colitis is an inflammatory condition of the colon involving eosinophil infiltration.
  • Concurrent autoimmune or inflammatory conditions can complicate the diagnosis and management of PSC.

Observation:

  • A 39-year-old male presented with new-onset diarrhea and abdominal pain.
  • The patient had a history of PSC diagnosed at age 26, treated with prednisolone.
  • Diagnostic workup revealed severe eosinophilic infiltration in the colonic mucosa.

Findings:

  • The patient was diagnosed with eosinophilic colitis, co-occurring with his established PSC.
  • This case highlights the potential for overlapping gastrointestinal and hepatobiliary inflammatory conditions.
  • Severe eosinophilic infiltration confirmed the diagnosis of eosinophilic colitis.

Implications:

  • This case underscores the importance of considering eosinophilic gastrointestinal disorders in patients with PSC presenting with new GI symptoms.
  • Concurrent PSC and eosinophilic colitis may require tailored treatment strategies addressing both conditions.
  • Further research is warranted to understand the potential shared pathophysiology and optimal management of these co-existing diseases.