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Gross Anatomy of Bone

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...

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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Blastomycosis of bone: a clinicopathologic study.

Richa Jain¹, Kamaljit Singh², Ihab Lamzabi¹

¹From the Departments of Pathology and.

American Journal of Clinical Pathology

|October 17, 2014

Summary

Blastomycosis osteomyelitis, often mimicking bone tumors, can be rapidly diagnosed with intraoperative frozen section. Early consideration in endemic areas improves patient outcomes for this rare fungal infection.

Keywords:

Blastomycosis Blastomycosis osteomyelitis Bone

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Area of Science:

Mycology
Infectious Diseases
Orthopedic Pathology

Background:

Blastomycosis osteomyelitis is a rare complication of Blastomyces dermatitidis infection.
Diagnosis is often delayed due to its infrequent occurrence and potential to mimic other conditions.
The utility of intraoperative consultation for rapid diagnosis has not been previously detailed.

Purpose of the Study:

To evaluate the role of intraoperative consultation in the diagnosis of blastomycosis osteomyelitis.
To review clinicopathologic features of blastomycosis osteomyelitis and arthritis.
To assess the diagnostic accuracy of frozen section for this condition.

Main Methods:

Retrospective chart review of 14 cases diagnosed between 2000-2010.
Analysis of clinicopathologic information, including presentation, affected sites, and diagnostic methods.
Evaluation of frozen section accuracy and correlation with microbiologic studies.

Main Results:

Twelve of 14 cases presented as bone tumors, predominantly in the lower extremities near the knee.
Septic arthritis was commonly secondary to adjacent osteomyelitis.
Frozen section correctly diagnosed granulomatous osteomyelitis in all 10 cases where it was performed.

Conclusions:

Blastomycosis osteomyelitis should be included in the differential diagnosis of bone tumors, especially in endemic regions.
Intraoperative frozen section enables rapid and accurate diagnosis.
Morphologic and microbiologic findings show strong correlation.