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Development of the Lymphatic System

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

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Related Experiment Video

Updated: Apr 22, 2026

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Primary intrathymic lymphangioma.

Stefano Licci¹, Francesco Puma², Marta Sbaraglia³

¹From Department of Pathology, "Santo Spirito" Hospital, Rome, Italy; stefano.licci@hotmail.it.

American Journal of Clinical Pathology

|October 17, 2014

Summary

This summary is machine-generated.

This study reports a rare case of mediastinal lymphangioma specifically within the thymus. Intrathymic lymphangioma is a crucial consideration for diagnosing mediastinal cysts in patients.

Keywords:

Cyst Lymphangioma Mediastinum Thymus

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Area of Science:

Pathology
Thoracic Surgery
Pediatric Surgery

Background:

Lymphangiomas are benign lymphatic malformations that can occur anywhere in the body.
While most common in the head and neck, they rarely present in the mediastinum.

Observation:

This report details a unique case of a lymphangioma with an intrathymic location within the mediastinum.
This specific intrathymic localization has not been previously documented in medical literature.

Findings:

The study presents the gross and microscopic pathological features of this rare intrathymic lymphangioma.
Clinicopathologic signatures of this entity are discussed.

Implications:

Intrathymic lymphangioma should be included in the differential diagnosis for mediastinal cystic lesions.
This finding is relevant for both pediatric and adult patients presenting with such conditions.