Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Major depression in Down's syndrome.

A C Warren1, S Holroyd, M F Folstein

  • 1Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

The British Journal of Psychiatry : the Journal of Mental Science
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new scale for comprehensive assessment of psychopathology in Alzheimer's disease.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2011
Same author

25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services.

Neurology·2009
Same author

Multivitamin use and B vitamin status in a homebound elderly population.

The journal of nutrition, health & aging·2007
Same author

Interferon (IFN)-beta 1a and IFN-beta 1b block IFN-gamma-induced disintegration of endothelial junction integrity and barrier.

Endothelium : journal of endothelial cell research·2004
Same author

The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.

Nucleic acids research·2003
Same author

Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.

Nature·2002
Same journal

The pressurised leaky funnel: rethinking recruitment, selection and retention in the UK psychiatry workforce.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Cutting through stigma: psychiatry and neurosurgery working together.

The British journal of psychiatry : the journal of mental science·2026
Same journal

A fourth pillar for evidence-based medicine: implications for psychiatry - CORRIGENDUM.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Understanding negative perceptions of psychiatrists on social media: lessons from public discourse and professional self-reflection.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Attachment-informed psychopharmacology in psychiatric care.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Acceptability and accuracy of point-of-care monitoring of lithium levels.

The British journal of psychiatry : the journal of mental science·2026
See all related articles

Major depression can mimic dementia in individuals with Down's syndrome (DS). Prompt diagnosis and electroconvulsive therapy (ECT) offer effective treatment for depression in DS patients, improving cognitive and behavioral symptoms.

Area of Science:

  • Neurology
  • Geriatrics
  • Psychiatry

Background:

  • Down's syndrome (DS) is associated with an increased risk of dementia, often resembling Alzheimer's disease.
  • Cognitive and behavioral changes in DS can be challenging to interpret.

Observation:

  • Five patients with DS presented with cognitive and behavioral decline, initially suspected as dementia.
  • Two patients were misdiagnosed with Alzheimer's disease due to overlapping symptoms.

Findings:

  • The patients were diagnosed with major depression, not Alzheimer's disease.
  • Key differences in presentation between major depression and Alzheimer's disease in DS were identified.

Implications:

  • Distinguishing major depression from Alzheimer's disease is crucial for accurate diagnosis and treatment in DS.

Related Experiment Videos

  • Electroconvulsive therapy (ECT) shows promise as an effective treatment for major depression in the DS population.