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Scatter factor and other regulators of cell mobility
British Medical Bulletin
|April 1, 1989
Summary
The scatter factor, a protein released by fibroblasts, influences epithelial cell behavior and early embryo development. It differs from autocrine motility factor, suggesting a broader role for cytokines in regulating cell movement.
Area of Science:
- Cell Biology
- Developmental Biology
- Biochemistry
Background:
- Fibroblasts release a protein known as scatter factor.
- This protein affects epithelial cell characteristics and early embryo development.
Purpose of the Study:
- To characterize the scatter factor and its effects on cells.
- To differentiate scatter factor from autocrine motility factor.
Main Methods:
- Cultured cell lines (fibroblasts and epithelial cells).
- Observation of cell morphology, motility, and attachment.
- Biochemical analysis.
Main Results:
- Scatter factor (62K protein) alters epithelial cell mobility, morphology, and attachment.
- Fibroblasts and cell growth are largely unaffected.
- Scatter factor exhibits a paracrine role and lacks association with tumor cells, distinguishing it from autocrine motility factor.
Conclusions:
- Scatter factor is a key regulator of epithelial cell behavior.
- It plays a role in early embryonic development.
- Scatter factor and autocrine motility factor may represent a cytokine group regulating cell motility.