Related Experiment Video

Updated: Apr 22, 2026

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
05:25

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration

Published on: May 24, 2024

3.3K

Liver enzymes and psychological well-being response to aerobic exercise training in patients with chronic hepatitis C

Shehab M Abd El-Kader1, Osama H Al-Jiffri2, Fadwa M Al-Shreef2

  • 1Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.

African Health Sciences
|October 17, 2014
PubMed

Insights

Aerobic exercise training significantly improved liver enzymes and psychological well-being in patients with chronic hepatitis C. This intervention offers a beneficial addition to standard medical care for CHC patients.

Area of Science:

  • Hepatology
  • Exercise Physiology
  • Clinical Psychology

Background:

  • Chronic hepatitis C (CHC) significantly impacts patients' physical and psychological health.
  • Understanding the effects of interventions on CHC patients is crucial for improving quality of life.

Purpose of the Study:

  • To assess the impact of aerobic exercise training on liver enzymes and psychological well-being in CHC patients.
  • To compare outcomes between CHC patients undergoing aerobic exercise and those receiving standard care.

Main Methods:

  • Fifty CHC patients were randomized into two groups: aerobic exercise plus standard treatment (Group A) or standard treatment alone (Group B).
  • Aerobic exercise intervention involved three sessions per week for three months.
  • Liver enzymes (ALP, ALT, AST, GGT) and psychological measures (BDI, POMS, RSES) were assessed.

Main Results:

  • Group A showed significant reductions in liver enzymes (ALP, ALT, AST, GGT) and depression/mood disturbance scores (BDI, POMS).
  • Group A demonstrated a significant increase in self-esteem (RSES).
  • Group B exhibited no significant changes in the measured parameters, with significant differences observed between groups post-intervention.

Conclusions:

  • Aerobic exercise training is an effective intervention for improving liver enzyme profiles in CHC patients.
  • Aerobic exercise training positively impacts psychological well-being, reducing depression and enhancing self-esteem in CHC patients.
  • Aerobic exercise training represents a valuable complementary therapy for managing chronic hepatitis C.
Abstract

Keywords:
aerobic exercisechronic hepatitis Cliver enzymespsychological well-being

More Related Videos

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies09:51

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

2.1K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.3K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
377
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
6.4K
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.7K
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
24
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
864