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Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

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Polymeric nanoparticle engineering: from temperature-responsive polymer mesoglobules to gene delivery systems.

Emi Haladjova¹, Natalia Toncheva-Moncheva, Margarita D Apostolova

¹Institute of Polymers, Bulgarian Academy of Sciences , "Akad. G. Bonchev" St. 103A, 1113 Sofia, Bulgaria.

Biomacromolecules

|October 17, 2014

Summary

Researchers developed a new method for creating nano- and microcapsules using thermoresponsive polymer (TRP) templates. This technique allows for controlled loading of bioactive compounds without covalent attachment, offering promising applications in drug delivery.

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Area of Science:

Polymer Chemistry
Materials Science
Biotechnology

Background:

Developing efficient methods for nano- and microcapsule preparation is crucial for drug delivery and biomaterial applications.
Thermoresponsive polymers (TRPs) offer unique properties for controlled release systems.
Existing methods for loading biomacromolecules into capsules can be complex and may involve covalent attachment, potentially affecting bioactivity.

Purpose of the Study:

To introduce a novel, template-based approach for synthesizing nano- and microcapsules in aqueous solutions.
To demonstrate the controlled loading of biomacromolecules into these capsules without covalent modification.
To explore the potential of these capsules as reservoirs, carriers, and transferring agents for biologically active substances.

Main Methods:

Utilizing thermoresponsive polymer (TRP) templates, termed mesoglobules, for capsule formation.
Employing seeded radical copolymerization to coat the mesoglobule templates.
Implementing a core dissolution and removal process upon cooling to yield hollow capsules.
Investigating the loading efficiency and shell properties, including targeting ligand incorporation and porosity control.

Main Results:

Successful preparation of nano- and microcapsules using the mesoglobule templating method.
Demonstrated ability to entrap biomacromolecules during mesoglobule formation, enabling controlled loading.
Showcased the dissolution of mesoglobules upon cooling and the formation of stable capsule shells.
Successfully coated DNA complexes with cationic copolymers bearing TRP blocks.

Conclusions:

The described method provides a versatile and efficient route for producing nano- and microcapsules with tunable properties.
Mesoglobules serve as effective templates for creating capsules capable of carrying bioactive compounds without covalent attachment.
This approach holds significant promise for developing advanced drug delivery systems and biomaterials.