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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Apr 22, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

Signet-ring cell melanoma: a potential diagnostic pitfall.

Linda Kocovski¹, Salem Alowami

¹Department of Pathology and Molecular Medicine, McMaster University, St Joseph's Hospital, Hamilton, Ontario.

The American Journal of Dermatopathology

|October 17, 2014

Summary

This study details a rare case of signet-ring cell malignant melanoma, a histological variant that mimics other cancers. Immunohistochemical analysis confirmed the melanoma diagnosis, highlighting its importance in preventing misdiagnosis.

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Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

Area of Science:

Oncology
Dermatopathology

Background:

Malignant melanoma exhibits diverse clinical and histological presentations.
Signet-ring cell morphology is rare in melanoma but common in other malignancies like adenocarcinoma.

Observation:

A 62-year-old man presented with an enlarging nevus and erythema.
Biopsy revealed atypical epithelioid and signet cells, initially suspected as metastatic signet-cell carcinoma.
Immunohistochemical analysis was crucial for accurate diagnosis.

Findings:

The signet-ring cells stained positive for S100, vimentin, and melanoma cocktail.
This confirmed the diagnosis of primary signet-ring cell malignant melanoma.
The findings underscore the diagnostic challenge posed by signet-ring cell morphology in melanoma.

Implications:

Accurate diagnosis of signet-ring cell melanoma is critical to avoid misdiagnosis.
Immunohistochemistry is essential for differentiating melanoma from other signet-ring cell neoplasms.
This case highlights the importance of comprehensive histological examination and targeted diagnostics.