Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

9.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
9.3K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

6.1K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.1K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

15.9K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
15.9K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

7.1K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
7.1K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Osteopontin-loaded nanoarchaeosomes for enhanced osteogenesis and bone regeneration in osteoporotic zebrafish models.

Nanoscale·2026
Same author

Retinoic acid drives cell fate specification, maturation and retinal regionality in human retinal organoids.

Nature communications·2026
Same author

Red to near-infrared carbon dots: synthesis, cellular interactions, drug loading, and therapeutic applications.

Advanced drug delivery reviews·2025
Same author

Emerging technologies for personalised oro-maxillofacial bone regeneration: Design strategies and fabrication techniques.

Biomaterials·2025
Same author

Mesenchymal Stem Cell Senescence and Biomaterial-Based Next-Generation Rejuvenation Strategy.

Tissue engineering. Part B, Reviews·2025
Same author

3D Printed Materials with Nanovoxelated Elastic Moduli.

Advanced materials (Deerfield Beach, Fla.)·2025

Related Experiment Video

Updated: Apr 22, 2026

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

9.2K

Nanomaterials: the next step in injectable bone cements.

Young Jung No1, Seyed-Iman Roohani-Esfahani, Hala Zreiqat

  • 1Biomaterials & Tissue Engineering Research Unit, School of AMME, The University of Sydney, Sydney 2006, Australia.

Nanomedicine (London, England)
|October 17, 2014
PubMed
Summary

Injectable bone cements (IBCs) are crucial for bone repair but have limitations. Nanomaterials show promise for enhancing IBCs for better bone regeneration and load-bearing applications.

Keywords:
bioactive materialsbone tissue engineeringinjectable bone cementinjectable materialsnanocomposites

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.9K
An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

14.8K

Related Experiment Videos

Last Updated: Apr 22, 2026

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

9.2K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.9K
An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

14.8K

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Nanotechnology

Background:

  • Injectable bone cements (IBCs) are vital for maxillofacial and orthopedic applications, including treating osteoporotic fractures.
  • Existing IBCs like polymethylmethacrylate and calcium phosphate cement have limitations hindering widespread adoption.
  • Novel gel-based materials are mechanically insufficient for load-bearing uses.

Purpose of the Study:

  • To review the essential requirements for effective IBCs.
  • To analyze the benefits and drawbacks of current IBCs.
  • To explore the impact of nanomaterials on injectable bone systems for tissue regeneration.

Main Methods:

  • Literature review of existing injectable bone cements.
  • Analysis of current advancements in biomaterials for bone defect filling.
  • Investigation of nanomaterial integration in injectable systems.

Main Results:

  • Current IBCs face challenges related to mechanical properties and biocompatibility.
  • Nanomaterial incorporation is a key strategy for improving IBC performance.
  • Research is progressing towards developing mechanically robust and regenerative IBCs.

Conclusions:

  • There is a significant need for improved IBCs with enhanced mechanical strength and regenerative capacity.
  • Nanomaterials offer a promising avenue for overcoming the limitations of current injectable bone cement technologies.
  • Further research into nanomaterial-enhanced IBCs is essential for advancing bone defect treatment.