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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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Related Experiment Video

Updated: Apr 22, 2026

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
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Stored luminescence computed tomography.

Wenxiang Cong, Chao Wang, Ge Wang

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    |October 17, 2014
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    Summary
    This summary is machine-generated.

    Stored luminescence computed tomography uses x-ray pre-excited phosphor nanoparticles for enhanced molecular imaging. This method improves nanophosphor localization and image resolution in biological objects.

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    Area of Science:

    • Biomedical Optics
    • Nanotechnology
    • Medical Imaging

    Background:

    • Phosphor nanoparticles (NPs) exhibit luminescence when stimulated by near-infrared (NIR) light after x-ray pre-excitation.
    • These NPs can be functionalized as optical probes for molecular imaging applications.
    • X-ray excitation offers deeper penetration and better localization within biological tissues compared to traditional optical methods.

    Purpose of the Study:

    • To introduce and validate a novel imaging technique: stored luminescence computed tomography (SLCT).
    • To reconstruct the spatial distribution of nanophosphors within an object using SLCT.
    • To demonstrate the potential of SLCT for enhanced molecular imaging with improved accuracy and resolution.

    Main Methods:

    • Pre-excitation of phosphor nanoparticles using collimated x-ray beams or focused x-ray waves.
    • Stimulation of pre-excited NPs with variable NIR light patterns.
    • Sequential detection of stored luminescence signals.
    • Application of computed tomography principles for image reconstruction of nanophosphor distribution.

    Main Results:

    • Demonstrated feasibility of SLCT through realistic numerical studies.
    • Showcased improved localization and deeper penetration capabilities due to x-ray propagation.
    • Highlighted the potential for higher image resolution and more accurate reconstruction through sequential luminescence detection.

    Conclusions:

    • Stored luminescence computed tomography is a promising technique for molecular imaging.
    • The method leverages x-ray pre-excitation and NIR stimulation of phosphor nanoparticles.
    • SLCT offers significant advantages in terms of imaging depth, localization, and resolution for biological applications.