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Related Experiment Videos

Selenium supplementation does not alter platelet activation in subjects with normal selenium status.

M Mutanen1, L Viita, H M Mykkänen

  • 1Department of Nutrition, University of Helsinki, Finland.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|January 1, 1989
PubMed
Summary

Selenium supplementation did not affect platelet function markers like beta-thromboglobulin (beta TG) and platelet factor 4 (PF4) in women with normal selenium status. Antioxidant levels also remained unchanged, indicating no link between selenium and platelet activity in this group.

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Area of Science:

  • Biochemistry
  • Nutrition Science
  • Hematology

Background:

  • Platelet specific proteins, beta-thromboglobulin (beta TG) and platelet factor 4 (PF4), are crucial indicators of platelet activation.
  • Selenium (Se) is an essential trace element with known antioxidant properties.
  • The impact of selenium supplementation on platelet function in individuals with adequate selenium status requires further investigation.

Purpose of the Study:

  • To investigate the effect of selenium supplementation on plasma concentrations of beta TG and PF4.
  • To assess the impact of selenium on other markers of the body's antioxidative status.
  • To determine any relationship between selenium supplementation and platelet function in young women with normal selenium levels.

Main Methods:

  • A double-blind protocol was employed.

Related Experiment Videos

  • Twenty young women with normal selenium status participated.
  • Selenium was supplemented at 150 micrograms/day for 4 weeks, with measurements of plasma Se, beta TG, PF4, alpha-tocopherol, retinol, uric acid, and whole blood glutathione.

    • Main Results:

    • Selenium supplementation did not significantly alter plasma selenium concentrations.
    • Plasma levels of beta TG and PF4 remained unchanged.
    • No significant changes were observed in other measured antioxidative status parameters.

    Conclusions:

    • Selenium supplementation does not appear to affect platelet function in individuals with normal selenium status.
    • The body's antioxidative status markers were not influenced by short-term selenium supplementation in this cohort.
    • Results suggest no discernible relationship between selenium supplementation and platelet activity in subjects with adequate selenium levels.