Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship between plasma atriopeptin concentration and function in the conscious primate.

C Hoegler1, J McIntyre, G Zeballos

  • 1Department of Physiology, New York Medical College, Valhalla.

The Journal of Pharmacology and Experimental Therapeutics
|December 1, 1989
PubMed
Summary

Atriopeptins (APs) significantly increase urine flow and sodium excretion in primates. The circulating form, AP-28, showed potent renal effects, with sodium excretion acting independently of other renal functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accidental lipid overdose in a preterm infant: A case report.

Journal of neonatal-perinatal medicine·2023
Same author

A British Society for Haematology Guideline: Diagnosis and management of thrombotic thrombocytopenic purpura and thrombotic microangiopathies.

British journal of haematology·2023
Same author

Measurements of Argon-39 from locations near historic underground nuclear explosions.

Journal of environmental radioactivity·2021
Same author

Evidence review of physical distancing and partition screens to reduce healthcare acquired SARS-CoV-2.

Infection prevention in practice·2021
Same author

The Scientists' Collective 10-point proposal for equitable and timeous access to COVID-19 vaccine in South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

Distinct adaptation patterns between grip dynamics and arm kinematics when the body is upside-down.

Journal of neurophysiology·2021

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Physiology

Background:

  • Atriopeptins (APs) are peptide hormones involved in regulating fluid and electrolyte balance.
  • Understanding the specific renal actions of different atriopeptin forms is crucial for comprehending their physiological roles.

Purpose of the Study:

  • To investigate the renal effects of atriopeptins (APs) 24, 21, and 28 in conscious primates (Macaca fascicularis).
  • To determine the dose-response relationship and biological half-life of APs in relation to renal function.

Main Methods:

  • Administration of AP-24, AP-21, and AP-28 to conscious macaques.
  • Measurement of urine flow rate, sodium excretion, plasma immunoreactive AP levels, arterial pressure, and heart rate.
  • Analysis of the relationship between plasma AP levels and various renal parameters.

Related Experiment Videos

Main Results:

  • AP-24 and AP-28 significantly increased urine flow rate and sodium excretion, with AP-28 showing slightly greater effects.
  • AP-21 exhibited markedly reduced effects compared to AP-24 and AP-28.
  • Direct linear relationships were observed between plasma AP levels and renal function, with a distinct mechanism for sodium excretion.
  • The biological half-life for sodium excretion was shorter than for urine flow and potassium excretion, suggesting independence from GFR and UFR.

Conclusions:

  • Atriopeptins exhibit potent dose-dependent renal effects in primates, influencing urine flow and electrolyte excretion.
  • Sodium excretion appears to be regulated by a mechanism distinct from urine flow and glomerular filtration rate.
  • The findings highlight the significant role of atriopeptins in renal function, particularly in sodium handling.