Related Experiment Videos
[Simulation of ovulation using two types of LH-RH agonists]
R Frydman1, J Belaisch-Allart, H Fernandez
1Hôpital Antoine Béclère, Clamart, France.
Journal of Steroid Biochemistry
|October 1, 1989
Summary
Luteinizing hormone-releasing hormone (LH-RH) agonists in IVF show similar pregnancy rates between long and short protocols. The short protocol resulted in a higher ovarian response before human chorionic gonadotropin (hCG) administration.
Area of Science:
- Reproductive endocrinology
- In vitro fertilization (IVF)
Background:
- Luteinizing hormone-releasing hormone (LH-RH) agonists are frequently employed in assisted reproductive technologies.
- Optimizing ovulation stimulation protocols is crucial for IVF success.
Purpose of the Study:
- To compare the efficacy of two distinct protocols utilizing LH-RH agonists in IVF.
- To evaluate ovarian response and pregnancy rates between long and short LH-RH agonist protocols.
Main Methods:
- Retrospective analysis of IVF cycles using long versus short LH-RH agonist protocols.
- Comparison of ovarian response markers on the day of human chorionic gonadotropin (hCG) administration.
- Assessment of ongoing pregnancy rates per initiated treatment cycle.
Main Results:
- A statistically significant higher ovarian response was observed in the short protocol group (69%) compared to the long protocol group (56%) on the day of hCG administration (P < 0.001).
- The ongoing pregnancy rates per treatment cycle were comparable between the two groups, with 18% in the long protocol and 16% in the short protocol.
Conclusions:
- Both long and short LH-RH agonist protocols yield similar ongoing pregnancy rates in IVF.
- The short protocol demonstrates a superior ovarian response prior to hCG administration, suggesting potential benefits in stimulation efficiency.