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Updated: Apr 22, 2026

Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy
Published on: March 25, 2022
Profiling individual human red blood cells using common-path diffraction optical tomography
Youngchan Kim1, Hyoeun Shim2, Kyoohyun Kim1
1Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
Abstract:
Due to its strong correlation with the pathophysiology of many diseases, information about human red blood cells (RBCs) has a crucial function in hematology. Therefore, measuring and understanding the morphological, chemical, and mechanical properties of individual RBCs is a key to understanding the pathophysiology of a number of diseases in hematology, as well as to opening up new possibilities for diagnosing diseases in their early stages. In this study, we present the simultaneous and quantitative measurement of the morphological, chemical, and mechanical parameters of individual RBCs employing optical holographic microtomography. In addition, it is demonstrated that the correlation analyses of these RBC parameters provide unique information for distinguishing and understanding diseases.
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